Imagine for a minute: A company makes a vaccine that protects kids from a life-threatening disease but, with little warning, decides to stop selling it in the U.S.
That's exactly what happened last year in West Africa, for a vaccine against rotavirus — a disease that kills about 200,000 young children and babies each year.
As NPR reported in November, the pharmaceutical giant Merck & Co. Inc. announced it was ending a long-term agreement to supply its rotavirus vaccine, RotaTeq, at a reduced price to families in four West African countries. At the same time, the company began selling the vaccine in China, for more than 12 times the price.
Merck's decision meant that more than 2 million babies were at risk of missing the vaccine, health experts told NPR.
"You have a major manufacturer of a vaccine announcing that they're going to exit from the market, and it created a bit of a panic for countries that were accustomed to having this vaccine," says Deborah Atherly of the nonprofit PATH, which helps develop vaccines for low-income countries.
Now the situation has changed — for the good.
After NPR broke the news of Merck's pullout, other vaccine manufacturers stepped up to fill in the gap. "Because of these efforts, very few to no children will miss out on rotavirus vaccination in these four countries," Gavi wrote to NPR in an email.
This is a huge success story, Atherly says. "We deal with tons of challenges in global health, and this is one, in which the global health community rallying with the countries, has really created success."
Rotavirus is a ubiquitous infection. "Almost every child, whether you live in the U.S. or you live in a developing country, is infected with this disease," says Dr. Mathuram Santosham, a pediatrician at Johns Hopkins University who has studied the disease for more than 40 years.
In rich countries, the infections are rarely lethal but can be severe. Before the U.S. introduced the rotavirus vaccine in 2006, infections caused more than 50,000 hospitalizations each year, the Centers for Disease Control and Prevention says.
In poor countries, without good health care systems, rotavirus can be deadly. Children can have six to 20 bouts of diarrhea in a day and dehydrate extremely fast, Santosham says. "It is particularly important for the children in the poorest countries — and the poorest children in the poor countries — to receive this vaccine."
But the vaccine is expensive. Here in the U.S., it costs about $200 for a course of two-to-three doses administered in the first year of a baby's life. So in 2012, the two companies that manufacture a vaccine, Merck and GlaxoSmithKline, agreed to drastically reduce the price for poor countries to about $10 a course.
For six years, the pharmaceutical companies stuck to those agreements. GSK delivered nearly 220 million doses to 42 countries. And Merck delivered more than 30 million doses to four countries in West Africa — Burkina Faso, Ivory Coast, Mali, and São Tomé and Príncipe.
But last year, Merck informed UNICEF and Gavi that it would not ship about a third of those doses for 2018 and 2019. And in 2020, the company would stop supplying the vaccine altogether to West Africa. The company told NPR that "supply constraints" were preventing it from fulfilling its agreement to the West African countries. The company also expressed "deepest regret to all of the parties involved" in an email to NPR.
It looked like more than 2 million babies would go without the vaccine. At the time, GSK told NPR it wasn't able to help the countries in West Africa because the company was experiencing its own supply problems. "We also cannot confirm the availability of the doses necessary to support new programmes in 2019," the company wrote in an email.
But then after NPR's story aired, GSK changed course. The company is now filling in almost half of the vaccine gap left by Merck. Earlier this year, GSK begun supplying Rotarix to the Ivory Coast — where nearly a million babies are born each year. "GSK is pleased that we have sufficient capacity and hopes to fulfill the demand for Rotarix in Ivory Coast for as long as required," a spokesperson wrote in an email to NPR.
The other part of the vaccine gap will be filled largely by one of two Indian pharmaceutical companies. Last year, the World Health Organization gave its stamp of recommendation two new rotavirus vaccines, Rotavac and Rotasiil, which are manufactured by Bharat Biotech and Serum Institute of India, respectively. Back in November, health experts said three West African countries — Mali, Burkina Faso, and São Tomé and Príncipe — would eventually switch to these vaccines. But that was expected to take at least two years.
Now all three countries are speeding up the timeline and plan to roll out the new vaccine by 2020, says Heather Deehan, chief of UNICEF's Vaccine Centre. In the meantime, the countries are relying on stocks of the Merck vaccine to continue immunizations.
"As a result of a strong collaboration among UNICEF, the countries and manufacturers, there was no interruption in the countries' vaccine programs," Deehan says.
In a follow-up interview with NPR, Merck's chief marketing officer, Michael Nally, said that one reason the company ended its agreement with Gavi was because the competing vaccines were more desirable for low-income countries than RotaTeq. GSK's vaccine requires one less dose, while the Indian vaccines will be less expensive.
"We've had to come to a conversation around, we are probably not going to be the product of choice in those markets," Nally said.
In the meantime, Merck has successfully launched sales of RotaTeq in China. The vaccine is now available in at least seven Chinese provinces, and a course costs about $130, or about 12 times the cost of the vaccine in the West Africa. Merck's Chinese distributor, Chongqing Zhifei Biological Products Co., hopes to obtain more than $450 million worth of the vaccine in the next several years.
RACHEL MARTIN, HOST:
Two million, that is the number of babies who were at risk because the pharmaceutical company Merck stopped providing a lifesaving vaccine to several West African countries. At the same time, Merck was going to start selling the vaccine at a higher price to China. NPR broke that story last fall. And now we have good news to report. Those babies will still get the vaccine. As NPR's Michaeleen Doucleff reports, other companies are now stepping in.
MICHAELEEN DOUCLEFF, BYLINE: The vaccine is for a disease called rotavirus, which infects basically every child on the planet.
MATHURAM SANTOSHAM: Every child, whether you live in the U.S. or you live in a developing country, is infected with this disease.
DOUCLEFF: That's Dr. Mathuram Santosham, a Johns Hopkins University pediatrician and an expert on rotavirus. He says the disease causes very severe diarrhea. Here in the U.S., children can easily get treatment at a hospital. But in poor countries without good health care systems, rotavirus can be deadly.
SANTOSHAM: It can be a very severe disease. Like, I've seen kids die right in front of my eyes.
DOUCLEFF: Santosham says rotavirus still kills about 200,000 children and babies each year because families in poor countries can't afford the vaccine. Here in the U.S., it costs about $200 a course. So back in 2012, the two companies that manufacture the vaccine, Merck and GlaxoSmithKline, agreed to drastically reduce the price for low-income countries to about $10 a course. Merck would supply four countries in West Africa, and GlaxoSmithKline would supply 42 countries. Santosham says this was great news.
SANTOSHAM: Kids should not be denied a vaccine just because they belong to a poor country.
DOUCLEFF: Merck stuck to that agreement for six years. Then, last year, the company announced it was ending the agreement. At the same time, Merck started selling the vaccine to China at a much higher price. Deborah Atherly is at the nonprofit PATH, which helps develop vaccines for poorer countries. She says the global health community was alarmed.
DEBORAH ATHERLY: You have a major manufacturer of a vaccine announcing that they're going to exit from the market, and I think it created a bit of a panic for countries that were accustomed to having this vaccine.
DOUCLEFF: It also meant that more than 2 million babies in Burkina Faso, Ivory Coast, Mali and Sao Tome and Principe would go without the vaccine. That was November 2018. At the time, Merck told NPR in an email that the reason for the pullout was supply constraints. The company also expressed, quote, "deepest regret to all the parties involved." Soon after NPR reported that story, other vaccine manufacturers stepped up to fill in the gap.
GlaxoSmithKline is now supplying one country with the vaccine. And Atherly says two Indian companies, Bharat Biotech and Serum Institute of India, will supply the other countries. And Atherly says no child will miss out on immunization because of Merck's termination of the agreement.
ATHERLY: We do not anticipate that any countries will have a gap in vaccinating their children.
DOUCLEFF: And so you think of this as a pretty big success story.
ATHERLY: It is. We deal with tons of challenges in global health. And this is one where the global health community rallying around with the countries has really created success.
DOUCLEFF: A success that means millions of babies will now be protected against a deadly disease. Michaeleen Doucleff, NPR News. Transcript provided by NPR, Copyright NPR.