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  • Critics say a question about AIDS and African-American women had Vice President Dick Cheney and Democratic challenger Sen. John Edwards bumbling for answers in Tuesday's vice-presidential debate. NPR's Tony Cox talks to Pernessa Seele, founder and CEO of the organization Balm in Gilead, and Deneen Robinson, an AIDS advocate and mother who has been living with HIV for 12 years.
  • Also: Flooding displaces thousands of Palestinians in Gaza; Chile elects former president Michele Bachelet as its new president; and the Mega Millions jackpot could reach a new record.
  • Also: Al-Qaida threatens to kill an American hostage kidnapped in Yemen; the Ebola death toll tops 6,000; and Target Australia will stop selling "Grand Theft Auto V" because of violence to women.
  • A recent NPR/PBS News/Marist poll found nearly 6-in-10 voters say President Trump's top priority should be lowering prices. That concern is being expressed loudly in the swing state of Wisconsin.
  • Also: A lawsuit alleges Motel 6 shared guest information with immigration officials; Iranian anti-government protests continue; and nobody won the Powerball lotto - it's now worth $550 million!
  • Also: ISIS militants destroy another temple in Palmyra; there are three hurricanes in the Atlantic and Pacific Oceans; and Cubs pitcher Jake Arrieta tosses the 6th no-hitter of the majors' season.
  • The Tiny Desk series producer shares his favorite records of the year.
  • A toponym is a word derived from a geographical place name, like "champagne" or "sandwich" — play along as we ask them to identify other (lesser-known) toponyms.
  • Also: Turkey's prime minister will discuss Syria with President Obama at the White House; congressional panels OK cuts to the federal food stamp program; the formerly obscure Arctic Circle gains new member countries; and nobody has yet won the Powerball jackpot.
  • Surprise, anger, parenting and Lizzo: That's one way to sum up the list of the most engaging stories in 2019. Other big topics included consumerism and climate change — and officials behaving badly.
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