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In the deadliest plane crash on U.S. soil in five years, 49 people died when a commuter airline crashed in Kentucky on Sunday. There are indications the plane may have used the wrong runway for takeoff.

In the past eight months, a video of a young guitarist playing a modern version of Johann Pachelbel's Canon in D Major has become a sensation on the Internet. The video has been viewed on YouTube.com more than 7.6 million times -- but nobody knew the identity of the guitarist. Recently, that changed.

Kenneth Lay, founder and vilified former chairman of scandal-ridden Enron Corp., died of a heart attack Wednesday morning. He was 64.

How much does the era you grow up in affect your personality? Psychologist Jean Twenge, a researcher at San Diego State University believes that a key factor in determining primary character traits is the generation that people are born in — and there may be credence to the notion of "The Greatest Generation."

On Thursday, an expert panel will tell the FDA whether a new vaccine against the human papilloma virus is ready to use. HPV can be sexually transmitted and can cause cervical cancer. It affects about 10,000 American women a year, and it kills about 3,700.

The race for New Orleans mayor will be decided on Saturday. Voters displaced by Hurricane Katrina will be able to cast absentee ballots until the polls close.

Todd Snider often writes songs with a slightly boozy country-rock swagger, paced by a steady intellectual metronome that's a tick or two ahead of most of his peers. Snider's new album, The Devil You Know, riffs on some of America's major political fault lines.

Commentator Marcos McPeek Villatoro shares thoughts on his experience acting as an "extra" on a hit television show.

New data obtained by NPR about the painkiller Vioxx show that all patients who took the drug were at increased risk for heart attack, stroke and other complications -- even those who took it for short periods of time. About 20 million Americans are estimated to have taken Vioxx before it was withdrawn in 2004.

A doping scandal has rocked the Tour de France before the cyclists have begun peddling. Favorites Jan Ullrich and Ivan Basso are among a list of cyclists who have been banned from the competition, which starts Saturday. Ullrich won the race in 1997.